How do hyaluronic acid injections work for osteoarthritis?

17. November 2025

Hyaluronic acid injections for osteoarthritis relieve joint pain and improve mobility. Find out how the therapy works and when it makes sense.

What is osteoarthritis and how does it develop?

Osteoarthritis is one of the most common joint diseases worldwide. It causes the joint cartilage to gradually break down, leading to pain, inflammation and restricted movement. The knee joint, hip and shoulder are often particularly affected. Typical symptoms are initial pain and limited mobility.

Hyaluronic acid – the natural joint lubricant

Hyaluronic acid is a natural component of joint fluid (synovial fluid). It ensures optimum lubrication and shock absorption in the joint. In osteoarthritis, the quality and quantity of the body’s own hyaluronic acid decreases, which puts more strain on the joint and causes pain.

How do hyaluronic acid injections work for osteoarthritis?

Treatment with hyaluronic acid injections aims to restore joint lubrication and reduce mechanical stress. The targeted injection into the affected joint improves lubrication, which leads to pain relief and better mobility. The therapy is particularly suitable for patients in the early to middle stages of osteoarthritis.

Different preparations – individual therapy

There are various hyaluronic acid preparations with different properties and modes of action. At our orthopaedic practice in Frankfurt, we select the right preparation for each individual patient. We also consider special preparations that can have a supportive effect on degenerative meniscus tears. As a rule, the treatment comprises a series of 3 to 5 injections at weekly intervals.

Safety and hygiene in the practice

To eliminate the risk of infection during treatment as far as possible, we carry out injections under sterile conditions in a separate operating room. This ensures maximum safety and gentle treatment.

What can you expect from the therapy?

The effect of hyaluronic acid injections usually becomes apparent within a few weeks. Many patients report

  • Significant pain relief
  • Improved joint mobility
  • Longer phases without pain, often several months
  • Better quality of life in everyday life and during physical activity

The duration of the effect varies, but is often between 6 and 12 months. The treatment can be repeated if necessary.

Who are hyaluronic acid injections suitable for?

The therapy is ideal for patients who

  • want to delay or avoid an operation
  • Have pain from osteoarthritis in the knee, hip or other joints
  • do not want or tolerate cortisone treatment
  • prefer gentle, conservative treatment

Conclusion: Modern orthopaedics for healthy joints

Hyaluronic acid injections are a proven, minimally invasive way of relieving joint pain caused by osteoarthritis and improving mobility. The individual selection of the preparations and the sterile procedure in our practice ensure safe and effective treatment.

Are you suffering from joint pain and would like to find out more about hyaluronic acid therapy?
Make an appointment now for a consultation at our orthopaedic practice in Frankfurt am Main. We will be happy to help you!